Non-surgical treatments have expanded rapidly in the field of aesthetic medicine, offering more targeted and biologically active solutions for skin ageing, dullness, and textural irregularities. One such treatment gaining traction across Asia and entering Western markets is Rejuran, sometimes referred to by celebs and media as the “salmon sperm facial.”
Despite its nickname, Rejuran is not cosmetic folklore. It is a scientifically developed injectable therapy using polynucleotides (PNs) derived from salmon DNA. These molecules aim to support natural skin regeneration and barrier function, offering a biologically based alternative to traditional dermal fillers or neurotoxin-based treatments.
This article is designed for individuals researching skin rejuvenation options, including those who are preparing for a consultation or exploring injectable therapies that do not alter facial structure. The following guide covers what Rejuran is, who it may be suitable for, how the treatment is performed, potential risks, recovery, cost factors, and how to choose a qualified practitioner. It also includes practical tips for aftercare and essential questions to ask during a consultation to support informed, patient-centered decision-making.
What is Rejuran?
Rejuran is a non-surgical injectable skin booster that uses polynucleotides (PNs), which are long chains of nucleotides—the molecular building blocks of DNA and RNA. In Rejuran, these are derived from purified salmon sperm DNA, chosen for its structural compatibility with human tissues and minimal risk of immune reaction.
Polynucleotides are believed to support a number of skin functions. They help encourage the repair and regeneration of skin cells by activating fibroblasts—cells responsible for producing collagen and elastin. These structural proteins contribute to smoother, firmer, and more elastic skin. PNs also enhance the extracellular matrix, the complex network of molecules that maintain the skin’s resilience and support. Improved blood flow and moisture retention further contribute to healthier skin texture and appearance. Additionally, these molecules may counter oxidative stress and inflammation, which are often associated with environmental damage and ageing.
Several formulations of Rejuran are available to suit different treatment goals. Rejuran Healer is widely used to improve skin texture, elasticity, and overall tone. Rejuran I is intended for more delicate and thin-skinned areas, such as under the eyes, and can help with dark circles and fine lines. Rejuran S is used specifically to manage acne scarring, while Rejuran HB combines PNs with hyaluronic acid for patients who need hydration alongside skin regeneration.
Rejuran does not function like dermal fillers or wrinkle-relaxing injections. Instead of altering facial volume or muscle activity, it serves as a skin-restorative agent that stimulates internal repair. This makes it suitable for patients looking for gradual improvement in skin quality with a more natural and biologically supportive approach.
Who Might Consider This Procedure?
Rejuran may be considered by individuals experiencing signs of early skin ageing, skin dullness, or residual effects from acne or dermatological treatments. It may also benefit those who have rough skin texture or enlarged pores that do not respond to topical treatments. Patients looking to improve their skin’s resilience, hydration, or tone without altering facial volume may find Rejuran an appealing option.
Individuals recovering from procedures such as laser treatments, peels, or microneedling may also consider Rejuran to support healing and reduce redness or pigmentation. Since the treatment focuses on cellular repair, it may be appropriate for patients concerned with superficial fine lines, uneven tone, or post-inflammatory sensitivity. Importantly, Rejuran is often selected by those who seek subtle enhancement rather than transformation.
Suitability depends on several factors. Most patients are aged 25 and older, although younger adults with acne scarring or chronic irritation may benefit. The treatment is compatible with all Fitzpatrick skin types and suitable for sensitive, oily, dry, or combination skin. It is not recommended for individuals with open wounds, active infections, autoimmune diseases, or bleeding disorders. Rejuran should also be avoided during pregnancy and breastfeeding.
Ultimately, an in-person assessment by a trained professional is needed to determine if Rejuran is a good fit. A tailored plan based on skin condition, lifestyle, and treatment history provides the best chance for satisfactory results.
Procedure Overview
The procedure starts with a detailed consultation. This includes a review of the patient’s medical history, current medications, previous aesthetic treatments, and lifestyle factors. The practitioner assesses the skin through visual examination and, in some cases, diagnostic imaging or hydration analysis. Treatment goals are discussed, and the most suitable Rejuran formulation is selected. Clinical photography may be used to track progress across sessions.
On the day of treatment, a topical numbing cream is applied to reduce discomfort. This is typically left on for 30 to 60 minutes. Once the area is numb, the practitioner injects the Rejuran solution into the dermis using either a fine needle or a microneedling injector device. The injection is often delivered in a grid-like pattern to ensure even distribution of the product. Areas with thinner skin, such as under the eyes, require specialised techniques to minimise trauma and side effects.
The treatment usually lasts between 30 and 60 minutes depending on the number of areas being treated. Following the procedure, small raised bumps or redness may be visible at the injection sites, but these typically subside within one to three days.
A series of three to four treatments spaced two to four weeks apart is often recommended for initial results. Maintenance sessions every four to six months help sustain the benefits over time.
Risks, Considerations, and Limitations
As with any medical procedure, Rejuran carries some risks. The most common side effects include temporary redness, mild swelling, and the appearance of small raised bumps at the injection sites. These effects usually resolve within 24 to 48 hours. Bruising may occur, particularly in areas with thinner skin, but is generally mild.
Less commonly, patients may experience itching, sensitivity, or minor discomfort in the treated areas. Infection is rare but can occur if proper hygiene protocols are not followed. Allergic reactions are extremely uncommon due to the highly purified nature of the polynucleotide extract, but any injectable carries a baseline risk of hypersensitivity.
Rejuran is not designed to treat deep wrinkles, sagging skin, or severe volume loss. It works best for superficial and moderate concerns and is not a substitute for surgical lifting or volumising procedures. Patients with highly reactive or compromised skin may require additional monitoring and support.
Clear communication, realistic expectations, and a personalised care plan are essential for managing potential limitations and enhancing safety. A qualified practitioner will help patients assess whether Rejuran alone is appropriate or if combination therapy may be more effective.
Recovery and Aftercare
The recovery experience with Rejuran is typically straightforward, though individual healing times may vary. Most patients resume normal activities the following day, though some choose to wait until visible bumps and redness subside.
Immediately after the procedure, injection points may appear raised or slightly swollen. This is a normal response and typically settles within 24 to 72 hours. Bruising or tenderness may persist a little longer, depending on the area and technique used.
Aftercare instructions typically include avoiding makeup for 24 hours, refraining from strenuous exercise or sauna use, and keeping the skin clean with gentle products. Sunscreen should be used consistently to protect the skin from UV exposure. Harsh skincare ingredients such as exfoliants, retinoids, and acids should be paused for several days unless advised otherwise.
Over the following weeks, patients may notice gradual improvements in skin hydration, smoothness, and brightness. Most visible changes become apparent after the second or third session, with cumulative effects continuing for several months.
How much is Rejuran?
The cost of Rejuran treatment varies depending on several factors including location, provider expertise, clinic type, and the area being treated. In major urban centres or luxury clinics, prices are generally higher due to overheads and specialised care.
A single session typically ranges from AUD $500 to $800 in Australia, £300 to £600 in the UK, and USD $400 to $700 in the USA. Full treatment plans usually include three or more sessions, with costs scaling accordingly. Some clinics offer bundled pricing for packages or include post-treatment skincare products as part of the service.
Additional expenses may include cosmetic consultation fees, skin analysis, or combination treatments. As Rejuran is an elective aesthetic procedure, it is not eligible for insurance reimbursement in most countries. Patients should discuss all expected costs in advance and ask what is included in the quoted price.
Choosing a Qualified Practitioner
Rejuran should only be performed by qualified healthcare professionals with appropriate training in injectable treatments and skin anatomy. In Australia, this includes FRACS-certified surgeons and AHPRA-registered doctors or nurses trained in aesthetics. In the UK, providers should be registered with the GMC and ideally have additional aesthetic certification. In the USA, board-certified dermatologists and plastic surgeons are the most appropriate practitioners for this treatment.
When evaluating a provider, patients should verify credentials, ask about experience with Rejuran or similar injectables, and request to see before-and-after images of previous patients with similar skin types or concerns. Reputable clinics will offer a clean, accredited facility and transparent pricing. Patients should feel comfortable asking questions and should never feel pressured to proceed with treatment.
Before and After Photos
Questions to Ask During a Consultation
Preparing thoughtful questions before a consultation can help patients make informed decisions. Examples include:
- Is Rejuran suitable for my specific skin condition or concern?
- How many sessions will I need to see visible improvement?
- Which formulation of Rejuran is recommended for me?
- What kind of results should I realistically expect, and over what time frame?
- What side effects should I be prepared for, and how can I minimise them?
- Can Rejuran be combined with other treatments, such as laser or microneedling?
- What aftercare steps do I need to follow to ensure optimal results?
A practitioner should be able to provide clear, evidence-based answers and support a patient-centered approach to care.
FAQs About Rejuran
Final Thoughts
Rejuran represents a modern approach to skin health, rooted in regenerative science rather than surface-level correction. For individuals looking for a treatment that supports skin function and appearance from within, Rejuran offers a promising option. Unlike fillers or wrinkle relaxers, Rejuran works gradually, aiming to strengthen the skin’s natural structure and promote a more hydrated, even, and resilient complexion over time.
The procedure is typically well tolerated, with a short recovery period and a safety profile that suits a wide range of skin types and tones. It appeals especially to those who value subtle, cumulative improvements and who wish to avoid more invasive or transformative procedures. Still, it is not a one-size-fits-all solution, and results depend on appropriate patient selection, correct application, and a well-planned treatment series.
Patients considering Rejuran should approach the decision thoughtfully, focusing on consultation with experienced, credentialed professionals who prioritise education, ethical practice, and clinical transparency. Asking informed questions, understanding the science behind the treatment, and following aftercare advice closely will support better, longer-lasting outcomes.
As with all medical and aesthetic decisions, personalised care and realistic expectations are key. Rejuran may not be a cure-all, but for many people, it provides a meaningful step towards healthier, more resilient skin.
